2011
Toledo-Corral, C M; Davis, J N; Alderete, T L; Weigensberg, M J; Ayala, C T; Li, Y; Hodis, H N; Goran, M I
Subclinical atherosclerosis in Latino youth: progression of carotid intima-media thickness and its relationship to cardiometabolic risk factors Journal Article
In: J. Pediatr., vol. 158, no. 6, pp. 935–940, 2011.
Abstract | BibTeX | Tags: diabetes risk, ectopic fat, IMT
@article{pmid21238987,
title = {Subclinical atherosclerosis in Latino youth: progression of carotid intima-media thickness and its relationship to cardiometabolic risk factors},
author = {C M Toledo-Corral and J N Davis and T L Alderete and M J Weigensberg and C T Ayala and Y Li and H N Hodis and M I Goran},
year = {2011},
date = {2011-06-01},
journal = {J. Pediatr.},
volume = {158},
number = {6},
pages = {935--940},
abstract = {To assess carotid artery intima-media thickness (CIMT) change over 2 years in overweight Latino adolescents and examine its relationship to cardiometabolic risk. Seventy-two healthy overweight male and female Latino adolescents (mean age, 14.5 ± 1.7 years; mean body mass index, 31.5 ± 6.9 kg/m(2)) were evaluated at baseline and 2 years later for CIMT by high-resolution B-mode ultrasound, the metabolic syndrome and its features, body composition by dual-energy x-ray absorptiometry and magnetic resonance imaging, glucose/insulin measures by fasting blood, and oral and intravenous glucose tolerance tests. Baseline CIMT did not differ from 2-year follow-up; however, 38 participants increased CIMT (0.017 ± 0.003 mm; +2.8%) and 34 decreased or remained the same (-0.019 ± 0.002 mm; -3.1%). ANCOVA analyses showed that participants with CIMT progression had higher baseline low-density lipoprotein (LDL)-cholesterol and total cholesterol (91.3 ± 3.4 and 150.3 ± 3.9 mg/dL) compared with those with CIMT non-progression (78.1 ± 3.6 and 135.6 ± 4.2 mg/dL, P < .05), independent of sex, baseline CIMT, age, and height. In multivariate regression, LDL-cholesterol was the sole predictor of CIMT progression, but the effect was small (odds of CIMT progression increased by 3% for each 1 mg/dL higher baseline LDL-cholesterol; 95% CI, 1.004 to 1.006},
keywords = {diabetes risk, ectopic fat, IMT},
pubstate = {published},
tppubtype = {article}
}
To assess carotid artery intima-media thickness (CIMT) change over 2 years in overweight Latino adolescents and examine its relationship to cardiometabolic risk. Seventy-two healthy overweight male and female Latino adolescents (mean age, 14.5 ± 1.7 years; mean body mass index, 31.5 ± 6.9 kg/m(2)) were evaluated at baseline and 2 years later for CIMT by high-resolution B-mode ultrasound, the metabolic syndrome and its features, body composition by dual-energy x-ray absorptiometry and magnetic resonance imaging, glucose/insulin measures by fasting blood, and oral and intravenous glucose tolerance tests. Baseline CIMT did not differ from 2-year follow-up; however, 38 participants increased CIMT (0.017 ± 0.003 mm; +2.8%) and 34 decreased or remained the same (-0.019 ± 0.002 mm; -3.1%). ANCOVA analyses showed that participants with CIMT progression had higher baseline low-density lipoprotein (LDL)-cholesterol and total cholesterol (91.3 ± 3.4 and 150.3 ± 3.9 mg/dL) compared with those with CIMT non-progression (78.1 ± 3.6 and 135.6 ± 4.2 mg/dL, P < .05), independent of sex, baseline CIMT, age, and height. In multivariate regression, LDL-cholesterol was the sole predictor of CIMT progression, but the effect was small (odds of CIMT progression increased by 3% for each 1 mg/dL higher baseline LDL-cholesterol; 95% CI, 1.004 to 1.006
Lê, K A; Ventura, E E; Fisher, J Q; Davis, J N; Weigensberg, M J; Punyanitya, M; Hu, H H; Nayak, K S; Goran, M I
Ethnic differences in pancreatic fat accumulation and its relationship with other fat depots and inflammatory markers Journal Article
In: Diabetes Care, vol. 34, no. 2, pp. 485–490, 2011.
Abstract | BibTeX | Tags: diabetes risk, ectopic fat
@article{pmid21270204,
title = {Ethnic differences in pancreatic fat accumulation and its relationship with other fat depots and inflammatory markers},
author = {K A Lê and E E Ventura and J Q Fisher and J N Davis and M J Weigensberg and M Punyanitya and H H Hu and K S Nayak and M I Goran},
year = {2011},
date = {2011-02-01},
journal = {Diabetes Care},
volume = {34},
number = {2},
pages = {485--490},
abstract = {Visceral adipose tissue (VAT) and hepatic fat are associated with insulin resistance and vary by sex and ethnicity. Recently, pancreatic fat fraction (PFF) has also been linked with increasing obesity. Our aim was to assess ethnic and sex differences in PFF and its relationship to other fat depots, circulating free fatty acids (FFA), insulin secretion and sensitivity, and inflammation in obese adolescents and young adults. We examined 138 (40 males, 98 females) obese Hispanics and African Americans (13-25 years). Subcutaneous adipose tissue and VAT volumes, hepatic fat fraction (HFF), and PFF were determined by magnetic resonance imaging. Insulin sensitivity and β-cell function were assessed during an intravenous glucose tolerance test. Hispanics had higher PFF than African Americans (7.3 ± 3.8 vs. 6.2 ± 2.6%},
keywords = {diabetes risk, ectopic fat},
pubstate = {published},
tppubtype = {article}
}
Visceral adipose tissue (VAT) and hepatic fat are associated with insulin resistance and vary by sex and ethnicity. Recently, pancreatic fat fraction (PFF) has also been linked with increasing obesity. Our aim was to assess ethnic and sex differences in PFF and its relationship to other fat depots, circulating free fatty acids (FFA), insulin secretion and sensitivity, and inflammation in obese adolescents and young adults. We examined 138 (40 males, 98 females) obese Hispanics and African Americans (13-25 years). Subcutaneous adipose tissue and VAT volumes, hepatic fat fraction (HFF), and PFF were determined by magnetic resonance imaging. Insulin sensitivity and β-cell function were assessed during an intravenous glucose tolerance test. Hispanics had higher PFF than African Americans (7.3 ± 3.8 vs. 6.2 ± 2.6%