2011
Kelly, L A; Lane, C J; Weigensberg, M J; Toledo-Corral, C M; Goran, M I
Pubertal changes of insulin sensitivity, acute insulin response, and β-cell function in overweight Latino youth Journal Article
In: J. Pediatr., vol. 158, no. 3, pp. 442–446, 2011.
Abstract | BibTeX | Tags: diabetes risk, puberty
@article{pmid20888012,
title = {Pubertal changes of insulin sensitivity, acute insulin response, and β-cell function in overweight Latino youth},
author = {L A Kelly and C J Lane and M J Weigensberg and C M Toledo-Corral and M I Goran},
year = {2011},
date = {2011-03-01},
journal = {J. Pediatr.},
volume = {158},
number = {3},
pages = {442--446},
abstract = {To examine changes in insulin sensitivity (SI), compensatory acute insulin response (AIR), and β-cell function/disposition index (DI) across puberty in overweight Latino boys and girls. Latino children (n = 253) were followed annually for up to 5 years. Longitudinal modeling was used to examine changes in SI, AIR, DI, and fasting and 2-hour glucose and insulin across Tanner stage. In boys, SI decreased in early puberty with a recovery by late puberty. The compensatory increase in AIR was appropriate in early maturation, but after Tanner stage 3, AIR declined by more than that predicted from the recovery in SI. For girls, SI decreased in early puberty and across all stages of maturation. In early maturation, there was an appropriate compensatory increase in AIR, but after Tanner stage 3, AIR decreased. Thus, DI deteriorated across puberty in boys and girls. In overweight Hispanic youth, compensatory changes in insulin secretion fails after Tanner stage 3 in both sexes, indicating β-cell deterioration during this critical period of development, thus increasing risk for type 2 diabetes.},
keywords = {diabetes risk, puberty},
pubstate = {published},
tppubtype = {article}
}
To examine changes in insulin sensitivity (SI), compensatory acute insulin response (AIR), and β-cell function/disposition index (DI) across puberty in overweight Latino boys and girls. Latino children (n = 253) were followed annually for up to 5 years. Longitudinal modeling was used to examine changes in SI, AIR, DI, and fasting and 2-hour glucose and insulin across Tanner stage. In boys, SI decreased in early puberty with a recovery by late puberty. The compensatory increase in AIR was appropriate in early maturation, but after Tanner stage 3, AIR declined by more than that predicted from the recovery in SI. For girls, SI decreased in early puberty and across all stages of maturation. In early maturation, there was an appropriate compensatory increase in AIR, but after Tanner stage 3, AIR decreased. Thus, DI deteriorated across puberty in boys and girls. In overweight Hispanic youth, compensatory changes in insulin secretion fails after Tanner stage 3 in both sexes, indicating β-cell deterioration during this critical period of development, thus increasing risk for type 2 diabetes.